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A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF
A comprehensive in depth gene expression/regulation profile in Mycobacterium tuberculosis-infected macrophages
We hypothesised that the performance of variant prioriisation tools may vary by disease phenotype.
Epigenetically regulated genes have a great theranostic potential, especially in tumors with no apparent driver mutations.
Orm1 is induced in response to hepatic injury and executes liver regeneration by activating cell cycle progression in hepatocytes
CAGE in combination with single-molecule sequencing technology allows mapping of TSSs and genome-wide capture of promoter activities state cell populations.
Feilman Fellow; Head, Precision Health Research and Head, Translational Intelligence
Over the last two decades, transcriptomics has become a standard technique in biomedical research. We now have large databases of RNA-seq data, accompanied by valuable metadata detailing scientific objectives and the experimental procedures used. The metadata is crucial in understanding and replicating published studies, but so far has been underutilized in helping researchers to discover existing datasets.
SETBP1 Haploinsufficiency Disorder (SETBD) is characterised by mild to moderate intellectual disability, speech and language impairment, mild motor developmental delay, behavioural issues, hypotonia, mild facial dysmorphisms, and vision impairment. Despite a clear link between SETBP1 mutations and neurodevelopmental disorders the precise role of SETBP1 in neural development remains elusive.
Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response.