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Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human LifeHuman adenosine deaminases (ADAs) modulate the immune response: ADA1 via metabolizing adenosine, a purine metabolite that inhibits pro-inflammatory and Th1 cytokine production, and the multi-functional ADA2, by enhancing T-cell proliferation and monocyte differentiation. Newborns are relatively deficient in ADA1 resulting in elevated plasma adenosine concentrations and a Th2/anti-inflammatory bias compared to adults.
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Intrauterine growth restriction predisposes to airway inflammation without disruption of epithelial integrity in postnatal male miceEvidence from animal models demonstrate that intrauterine growth restriction (IUGR) alters airway structure and function which may affect susceptibility to disease. Airway inflammation and dysregulated epithelial barrier properties are features of asthma which have not been examined in the context of IUGR.
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A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discoveryPredicting treatment response or survival of cancer patients remains challenging in immuno-oncology. Efforts to overcome these challenges focus, among others, on the discovery of new biomarkers. Despite advances in cellular and molecular approaches, only a limited number of candidate biomarkers eventually enter clinical practice.
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Associations between ethnicity, social contact, and pneumococcal carriage three years post-PCV10 in FijiIndigenous iTaukei had greater frequency and intensity of contact compared with Fijians of Indian Descent
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Mental-health disparities between heterosexual and sexual-minority adolescents: Examining the role of informant discrepanciesUnderstanding informant discrepancies and their meaning is pivotal to designing surveys that generate robust insights into the health of sexual-minority adolescents
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Symptom-related distress among indigenous Australians in specialist end-of-life care: Findings from the multi-jurisdictional palliative care outcomes collaboration dataThese findings provide reassurance of reasonable equivalence of end-of-life outcomes for Indigenous patients who have been accepted for specialist palliative care
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Associations between negative life experiences and the mental health of trans and gender diverse young people in Australia: Findings from Trans PathwaysThe current results highlight the urgent need for better mental health care and provide insight into areas for targeted mental health interventions
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Women Migrants in Western Australia: Case Studies of Resilience and EmpowermentWe propose that women migrants, through alliances and collaboration, cross borders of learning and work towards generating change and transformation
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A prospective study investigating gross motor function of children with cerebral palsy and GMFCS level II after long-term Botulinum toxin type A useChildren with Cerebral Palsy, Gross Motor Function level II treated at a young age with repeated doses of Botulinum Toxin A maintain or improve their functional motor level
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Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed SubjectsThe presence of pleural plaques on radiologic imaging does not confer additional increase in the risk of lung cancer