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Role of stem cell precursors in tissues

We have recently published a paper identifying precursor populations in peripheral lung (2017), and have also discovered that these populations can be found in multiple tissues.

Attenuation of maternal inflammatory responses during pregnancy to promote normal immune and behavioral outcomes in the offspring

This study will identify how the immune system contributes to neurodevelopmental outcomes and will investigate the use of an agent from traditional medicines.

The impact of Influenza infection during early life on immune development

This study will investigate the why disease is worse in infants and how early life viral infection impacts the developing immune system.

Mapping changes in immune cell populations in gestational tissues over the course of pregnancy

This is a strategic “pilot” project in which we are seeking basic information on the immune cell content of gestational tissues.

Long-term derangement of antigen presenting cell populations in the respiratory tract following Influenza A infection

This project investigates how different populations of cells within the respiratory tract immune system are altered during a viral infection.

Finding the cellular explanation for recurrent asthma exacerbations

This study is designed to identify the specific unique immune cell response that occurs in these children with recurrent disease.

Targeting the mucosal immune system in a pregnant mouse model to prevent experimental allergic airways disease in the offspring

Studies in Europe show exposure of pregnant women to high levels of microbial products stimulate immune function maturation in their offspring

The cellular effects of estrogen on allergic asthma

The study aims to identify the mechanism for this so that this knowledge can be used to better treat asthma and allergies in both males and females.

Mechanisms of IgE sensitization

This project investigates how cells of the immune system respond to substances to cause allergies to help develop new treatments.

Targeting the mucosal immune system in a mouse model to prevent pregnancy complications following maternal bacterial infection

This work is the first step to develop safe treatments for pregnant mums to protect against preterm delivery and low birth weight caused by maternal infections.